… of tissue and that melanin pigment synthesized in vivo is … as a polymerization precursor is
capable of producing melanin … display reduced virulence in mice and decreased melanization …

… We will particularly focus on Cryptococcus neoformans and … oxidized and polymerized to
produce DOPA melanin [8]. … Melanin synthesis needs to occur in a contained environment …

… , DOPA-melanin through the polymerization of dihydroxyindole (… Camacho are Cryptococcus
neoformans (top left) and C. … neoformans requires exogenous precursors for the synthesis …

… Pyomelanin is produced by the polymerization of homogentisic acid, one of the … Melanin
is a critical virulence factor in the basidiomycete fungal pathogen Cryptococcus neoformans, …

… METH-treated mice infected with … neoformans melanin is synthesized by a single
copper-dependent laccase enzyme encoded by the LAC1 gene through the oxidative polymerization …

… that can serve as a precursor for cryptococcal melanin biosynthesis [58]. Another study …
was established by the finding that mice pre-treated with antibiotics prior to infection with C. …

… The results of an investigation showing that mice deficient in neutrophil serine proteases, …
groups in the melanin polymer [161]. In addition to its role in melanin synthesis, studies have …

… The fungus Cryptococcus neoformans is the causative agent … neoformans or merely increased
auto-polymerization of … Briefly, 25 µL of each EV preparation was allowed to react at 37 C …

… biosynthesis pathway is involved in melanization in C. … We next infected male and female
BALB/c mice with H99S to … neoformans culture we determined if the amount of melanin …

… neoformans is the production of melanin pigments, which are … via the oxidation and
polymerization of particular aromatic … neoformans for exogenous substrates to synthesize melanin …